648 Adipose-derived stem cells in wound healing: comparison with fibroblasts and keratinocytes interaction
نویسندگان
چکیده
منابع مشابه
Adipose-Derived Stem Cells, their Secretome, and Wound Healing
Adipose tissue is an abundant source of progenitor cells with multidifferentiation potential and these cells, termed adipose-derived stem cells (ASC), have become an important proposed treatment for use in wound healing. The ability of these cells to increase angiogenesis (vessels arise from other vessels) and vasculogenesis (vessels arise from progenitor cells), produce growth factors and cyto...
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Background: Cell therapy is one of the most challenging methods in the healing of burn wounds in the world. The present study aimed to determine the effect of collagen hydrogel with adipose-derived mesenchymal stem cells on burn wound healing in an animal model. Materials and Methods: The present study was experimentally performed on 24 Wistar rats. Burn wounds were created on the skin of rats...
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Burn wounds are a significant medical challenge today. Current treatment includes the use of skin grafts or wound healing scaffolds to protect the wound and promote healing. However, pre-existing conditions and factors such as smoking can compromise normal healing thru decreased growth factor production, prolonged inflammation, tissue hypoxia, reduced cellular migration and ECM deposition, and ...
متن کاملSkin wound healing following the spray of human abdominal adipose tissue-derived mesenchymal stem cells in diabetic male rat
Introduction: Diabetes is rising worldwide and impaired wound healing is one of its major complications. This study aimed to determine the effects of adipose-derived mesenchymal stem cells (MSCs) on wound healing in diabetic rats. Materials and Methods: In this experimental study, abdominal adipose tissue was obtained from 10 patients who underwent an abdominoplasty. MSCs were isolated from adi...
متن کاملImpact of Hyperglycemia and Low Oxygen Tension on Adipose-Derived Stem Cells Compared with Dermal Fibroblasts and Keratinocytes: Importance for Wound Healing in Type 2 Diabetes
AIM Adipose-derived stem cells (ASC) are currently proposed for wound healing in those with type 2 diabetes mellitus (T2DM). Therefore, this study investigated the impact of diabetes on adipose tissue in relation to ASC isolation, proliferation, and growth factor release and the impact of hyperglycemia and low oxygen tension (found in diabetic wounds) on dermal fibroblasts, keratinocytes, and A...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.07.653